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pentobarbital will reduce the extent or result of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Pitolisant exposure is lowered by fifty% if coadministered with solid CYP3A4 inducers.pentobarbital will decrease the extent or impact of etravirine by influencing hepatic/intestinal enzyme CYP3A4 me